Published Scientific Papers

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A randomized, open-label, cross-over pilot study investigating metabolic product kinetics of the palatable novel ketone ester, bis-octanoyl (R)-1,3-butanediol, and bis-hexanoyl (R)-1,3-butanediol ingestion in healthy adults

Growing interest in the metabolic state of ketosis has driven development of exogenous ketone products to induce ketosis without dietary changes. BH-BD was originally developed as Metabolic Switch®...

A Novel Powder Formulation of the Ketone Ester, Bis Hexanoyl (R)-1,3-Butanediol, Rapidly Increases Circulating ß-Hydroxybutyrate Concentrations in Healthy Adults

  Growing interest in the metabolic state of ketosis has driven development of exogenous ketone products to induce ketosis without dietary changes. BH-BD was recently developed as Metabolic Switch®...

Novel Ketogenic Ester Acutely Increases Circulating r- and s-ß-Hydroxybutyrate Concentrations in Healthy Adults

The Ketone Di-ester in Metabolic Switch® is proven to effectively induce ketosis in healthy adults.

Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure

Human liver disease is modeled in swine. Liver cells transplanted, forming ectopic livers that cured fatal disease.

Development of Ectopic Livers by Hepatocyte Transplantation Into Swine Lymph Nodes

Transplanted swine liver cells are engrafted into the lymph nodes, proliferated, and form ectopic mini-livers.

Engineering strategies for generating hypoimmunogenic cells with high clinical and commercial value

The engineering of allogeneic cells to be ‘hypoimmunogenic’, also referred to as ‘universal’, so that they evade a host's immune system would be transformative for regenerative medicine.